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Check FAQAbout Ahmed
Ahmed Hamed is a journalist based in Cairo Governorate, Egypt. I work in fields of photography,film making, Journalism and media training I believe that art and cultural initiatives can make huge positive shifts to communities as well I believe in the power of photography and how an image can make change, After my graduation from mass media faculty journalism department in the year 2008 I worked in 3 fields simultaneously , mass media and journalism, cultural project management and Human Rights. as I got experience in the field of film making through getting a grant from Egyptian film center to fund my first short documentary film the smell of the country : ****** and participated as a facilitator in the human rights educational program at Cairo institute for human rights since 2010 and worked as well as researcher on "Media and the parliamentary elections in Egypt 2010" research project since August 2012 I am working as a multimedia officer at Aswat Masriya News website responsible for making multimedia content connected to Egyptian political, social and cultural daily affairs and to moderate and train team of interns and stringers working with the website ****** ******
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Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties
Cancer remains a major global health challenge, with significant efforts and funding directed towards its treatment. Despite advancements, combating advanced cancers remains difficult. Overexpression of tyrosine kinases, particularly VEGF and its receptors (VEGFR), is linked to cancer proliferation and metastasis. Targeted therapeutic approaches are preferred to minimize side effects. This article reviews recent indole-containing compounds from 2012 to 2023 that show potential as antineoplastic agents and VEGFR inhibitors, highlighting important drugs, natural products, synthesized compounds, and promising leads.
Bioactive Metabolite from Endophytic Aspergillus versicolor SB5 with Anti-Acetylcholinesterase, Anti-Inflammatory and Antioxidant Activities: In Vitro and In Silico Studies
Endophytic fungi, particularly Aspergillus versicolor SB5, isolated from Juncus rigidus, produce secondary metabolites with significant biological activities. The study identified Physcion, a compound with potent anti-inflammatory, antioxidant, and anti-acetylcholinesterase properties. The research highlights the potential applications of these metabolites in agriculture, pharmacy, and medicine. The findings underscore the importance of endophytic fungi as a source of bioactive compounds, with detailed in vitro and in silico analyses supporting the therapeutic potential of Physcion.
Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, with limited treatment options due to late diagnosis and drug resistance. This study investigates the anti-proliferative effects of melatonin on human hepatoma HepG2 cells, focusing on cell cycle arrest and inflammation inhibition. Melatonin was found to reduce cell viability in a dose- and time-dependent manner, with significant effects at 1 mM and 2.5 mM concentrations. The study highlights melatonin's potential as a safe antitumor agent, capable of inducing cell cycle arrest at the G0/G1 phase and reducing inflammation by down-regulating various inflammatory mediators. However, melatonin's effects on apoptosis were found to be complex, with increased expression of anti-apoptotic genes and drug resistance-related genes. The findings suggest that melatonin could be used alone or in combination with other therapies for HCC treatment, but caution is advised due to its controversial responses.
Cholinesterase Inhibitors from an Endophytic Fungus Aspergillus niveus Fv-er401: Metabolomics, Isolation and Molecular Docking
The study investigates the anticholinesterase activity of metabolites from the endophytic fungus Aspergillus niveus, isolated from Foeniculum vulgare roots. Fifty-eight metabolites were identified, and the extract showed inhibitory effects on acetylcholinesterase and butyrylcholinesterase, which are relevant to Alzheimer's disease treatment. Two known metabolites, terrequinone A and citrinin, were isolated and showed moderate inhibitory activity. Molecular docking suggested that these compounds and others identified by molecular networking could be promising candidates for new Alzheimer's drugs.
Phase 2 study of venetoclax plus carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma
The phase 2 study investigates the combination of venetoclax, carfilzomib, and dexamethasone (VenKd) in patients with relapsed/refractory multiple myeloma (RRMM). The study found that the combination was well tolerated with no unexpected safety signals and demonstrated promising, durable response rates, including minimal residual disease (MRD) negativity. The study highlights the potential of venetoclax as a biomarker-driven treatment, particularly for patients with t(11;14) translocation, who showed higher response rates. The findings support further investigation of VenKd in prospective clinical studies, with plans to enroll approximately 65 patients with t(11;14) in an expansion cohort to deepen understanding of venetoclax's utility in this subgroup.
Bedouin band "al-Jerken" plays music using war remnants as instruments, in a form of resistance toward unstable security situation in North Sinai,
In response to the increase of sexual harassment in Egypt, a group of martial arts professionals established an initiative to teach basic self defense moves to young Egyptians for free.
12-year-old schoolboy, Ahmed Eid Sayed, witnessed the Egyptian army crackdown on the Giza pro-Morsi camp, adjacent to Cairo University on 14th August 2013. Ahmed explains what he saw using his toy soldiers and bottle tops.
"Mazahar" is a band trying to keep Egypt's old tradition of "Zar" from extinction. Zar represents a musical heritage from the south to keep away the evil spirits. It is more widespread in Upper Egypt, Sudan and Ethiopia.
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