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Check FAQAbout Quentin
Quentin Richard is a journalist based in Paris, France. With expertise in research, field interviews, shooting, audio capture, and video editing, I offer a valuable advantage when quick turnaround is vital. I excel in collaborating with other talented professionals to deliver exceptional results. Equipped with a 4K camera, I specialize in producing high-definition visuals for TV reports, documentaries, video clips, and commercial spots. Additionally, I have extensive experience as a steadycam operator, capturing stunning cinematic shots. As the founder of Supershot, my own production company, I have the ability to assemble a skilled shooting crew and post-production team. I possess a special talent for motion design, ensuring that the final product is visually captivating and engaging.
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Portfolio
The oncometabolite D-2-hydroxyglutarate promotes DNA hypermethylation at lineage-specific enhancers controlling microglial activation in IDHmut gliomas
Tumor-associated macrophages and microglia in IDHmut gliomas exhibit DNA hypermethylation at distal enhancers, leading to decreased expression of genes related to inflammatory responses and glycolytic metabolism. This is linked to the inactivation of transcription factors regulating microglial responses. D-2-hydroxyglutarate (D-2HG) exposure inhibits TET-mediated 5mC oxidation, reducing global 5hmC levels and altering enhancer landscapes. Depletion of D-2HG enhances microglial responses, suggesting oncometabolites disrupt immune cell function in tumor environments.
Mosquito aging modulates the development, virulence and transmission potential of pathogens
Host age variation significantly influences the evolution and transmission dynamics of pathogens in mosquitoes. The study focused on Anopheles coluzzii, a major malaria vector, and found that older mosquitoes (12-day-old) exhibited reduced competence in transmitting Plasmodium falciparum compared to younger ones. Despite shorter median longevities, infected older mosquitoes showed improved survival, suggesting infection may enhance longevity. The timing of sporozoite appearance remained consistent across age classes. Epidemiological modeling indicated a lower vectorial capacity for older mosquitoes, though still significant due to extended longevity with infection. These findings highlight the importance of considering age heterogeneity in ecological and epidemiological studies to inform targeted control strategies.
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