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About Simon
Simon Anderson is a London-based television and online video streaming news reporter and correspondent with a demonstrated history of live television reporting, on-location and breaking news coverage.
Services
Video Package (Web / Broadcast) Interview (Video / Broadcast) Vox Pop
+4
Topics
Breaking News Fact Checking
Portfolio
Phosphodiesterase-5 inhibitors and the heart: compound cardioprotection?
01 Oct 2023  |  heart.bmj.com  |  English  |  Phosphodiesterase-5 Inhibitors
Phosphodiesterase-5 inhibitors (PDE5is) like sildenafil, tadalafil, and vardenafil, known for treating erectile dysfunction and pulmonary arterial hypertension, show potential cardioprotective effects. They enhance the cGMP–PKG axis, reducing pathological hypertrophy, ischemic injury, and improving cell survival. Clinical studies indicate PDE5is improve exercise capacity and ventricular function in heart failure with reduced ejection fraction (HFrEF), though results in heart failure with preserved ejection fraction (HFpEF) are mixed. PDE5is also show promise in reducing infarct size and arrhythmias post-myocardial infarction (MI). Despite proven safety profiles, their efficacy varies with heart failure subtypes, necessitating further clinical trials to confirm benefits in specific patient groups.
Tags:
Sildenafil Tadalafil Vardenafil Nature Trends Pharmacol Sci Nat Rev Drug Discov Nat Med Int J Clin Pract Heart JAMA Circulation Am Heart J Int J Cardiol J Am Coll Cardiol Pflugers Arch Basic Res Cardiol Drugs Exp Clin Res Br J Pharmacol Circ Heart Fail Am J Physiol Heart Circ Physiol Hypertens Res Acta Pharmacol Sin Circ Res Eur J Pharmacol J Mol Cell Cardiol Am J Physiol Heart Circ Physiol Inflammation Eur Urol J Am Coll Cardiol Circulation J Am Heart Assoc J Biol Chem Eur Heart J Mudd JO Kass DA Zhang M Ghofrani HA Osterloh IH Grimminger F Takimoto E Champion HC Li M Giuliano F Jackson G Montorsi F Anderson SG Hutchings DC Woodward M Andersson DP Trolle Lagerros Y Grotta A Salloum FN Abbate A Das A Westermann D Becher PM Lindner D Das S Maulik N Das DK Kukreja RC Nagy O Hajnal A Parratt JR Lewis GD Shah R Shahzad K Guazzi M Vicenzi M Arena R Kim KH Kim HK Hwang IC Zhuang XD Long M Li F Redfield MM Chen HH Borlaug BA Eisner DA Caldwell JL Kistamás K Díaz ME Trafford AW O’Neill SC Lee DI Vahebi S Tocchetti CG Chiang CE Luk HN Wang TM Piccirillo G Nocco M Lionetti M Herrmann HC Chang G Klugherz BD Frace AM Méry PF Fischmeister R Geelen P Drolet B Rail J Dustan Sarazan R Crumb WJ Beasley CM Mitchell MI Dmitrienko AA Jiang R Wang L Zhu CT Huang CK Chen BY Guo A Kim YJ Ohn JH Dibb KM Clarke JD Horn MA Koitabashi N Aiba T Hesketh GG Chau VQ Hoke NN Bishu K Hamdani N Mohammed SF Di Luigi L Corinaldesi C Colletti M Giannetta E Isidori AM Galea N Sperandio PA Oliveira MF Rodrigues MK Behr-Roussel D Oudot A Caisey S Paulus WJ Tschöpe C Andersen MJ Ersbøll M Axelsson A Melenovsky V Marhin T Hiemstra JA Chakir K Madhani M Hall AR Cuello F Fox KM Thadani U Ma PT Traverse JH Chen YJ Du R Halcox JP Nour KR Zalos G Robinson SD Ludlam CA Boon NA Viagra Cialis Levitra Cardioprotection Heart Failure Phosphodiesterase-5 Inhibitors
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