Shropshire, with its Shropshire Hills designated as an Area of Outstanding Natural Beauty, has been named one of the top ten global destinations by the Association of British Travel Agents. The county offers historical sites, such as the Stiperstones and the market town of Ludlow, which poet John Betjeman once called the loveliest town in England. The Feathers in Ludlow provides a comfortable stay for visitors. The county also has a rich sporting history, with the Wenlock Olympian Society, a precursor to the modern Olympics, still active today.

A study published in the Canadian Medical Association Journal has found that children who undergo four or more CT scans before the age of 18 have a significantly increased risk of developing certain cancers, such as intracranial tumors, leukemia, and non-Hodgkin lymphoma. The research, led by Yu-Hsuan Joni Shao, PhD, from Taipei Medical University, utilized the National Health Insurance Research Database in Taiwan to analyze data from over 85,000 participants. The study emphasizes the need for judicious use of CT scans and radiation-reducing techniques. Rebecca Smith-Bindman, MD, from the University of California, San Francisco, commented on the study, suggesting that the true risks might be underestimated due to the study's conservative methodology and reliance on estimated radiation doses.

A recent study has shown that postmenopausal women who adopted a reduced-fat vegan diet and included a daily serving of soybeans experienced a significant reduction in the frequency of menopausal hot flashes. The study, led by Neal Barnard, MD, president of the Physicians Committee for Responsible Medicine and adjunct professor at George Washington University, suggests that this dietary change could be considered a primary treatment for vasomotor symptoms. However, Susan Reed, MD, president of the North American Menopause Society, advises caution in interpreting the results due to the study's small size and nonblinded design. The trial, known as WAVS (Women's Study for the Alleviation of Vasomotor Symptoms), found a 78% decrease in total hot flash frequency and an 88% decrease in moderate to severe hot flashes in the intervention group. The study also noted improvements in quality of life and weight loss in the intervention group, with no apparent effect from equol-production status.

The Canadian Paediatric Society has released a position statement on the diagnosis of anxiety disorders in children and adolescents, providing guidance for pediatric health care providers. The statement, authored by Dr. Benjamin Klein of McMaster University, addresses the need for Canadian-specific guidelines amidst rising mental health issues and the impact of COVID-19. It includes recommendations for anxiety assessment, such as using the SCARED questionnaire and conducting thorough interviews. Dr. Klein emphasizes the complexity of diagnosing anxiety disorders, which requires a comprehensive approach and often involves extensive detective work due to the lack of straightforward diagnostic tests like MRI. The statement also highlights the importance of building trust with patients during assessments. The Canadian Academy of Child and Adolescent Psychiatry has endorsed the CPS position statement.

The article discusses the collaboration between New York oncologist Dr. Gabriel Sara and French actress and director Emmanuelle Bercot, which led to the creation of the film 'Peaceful' ('De Son Vivant'). Dr. Sara, who practices at Mount Sinai West, invited Bercot to observe his work, which inspired her to make a film based on his philosophy of honesty in dealing with cancer patients. Dr. Sara, who plays himself in the film, believes in the importance of truth and clarity for patients facing terminal illness. The film, which premiered at the 2021 Cannes Film Festival and was nominated for Best Film at the 2022 Lumières Awards, portrays the journey of a cancer patient and his family, emphasizing the need for truth and acceptance. Dr. Sara's unique approach to patient care, including regular tango performances and personalized ties, is highlighted as a means to connect with and support patients through their treatment.

A study involving the Karolinska Institutet, University of Bristol, and Sun Yat-Sen University has found that childhood obesity is a risk factor for most subtypes of adult-onset diabetes. The study, published in Diabetologia, utilized Mendelian randomization with data from genome-wide association studies to establish a causal link between childhood body size and adult diabetes. The research identified genetic variations associated with obesity and diabetes, finding that childhood obesity is causally associated with all diabetes subtypes except for mild age-related diabetes. The study suggests that early weight control in children could be crucial in preventing various forms of adult-onset diabetes. The research was supported by various councils and foundations, and one coauthor is affiliated with GlaxoSmithKline.

The article discusses the impact of Celine Dion's diagnosis of stiff person syndrome (SPSD) on raising awareness of the condition. Experts like Dr. Scott D. Newsome from the Johns Hopkins Stiff Person Syndrome Center and Dr. Marinos C. Dalakas from Thomas Jefferson University express concerns about both underdiagnosis and overdiagnosis of SPSD. The article highlights the complexity of diagnosing SPSD due to its heterogeneity and the lack of definitive diagnostic markers. It also touches on the autoimmune nature of SPSD and the associated comorbidities, as well as the challenges posed by non-specific autoantibodies and seronegative cases in understanding and treating the disorder.

The article describes the vibrant atmosphere in Marrakech, Morocco, especially during the country's successful run in the World Cup. The journalist, Kate Johnson, recounts her experiences in the city, from the bustling Djemaa el-Fna square to the tranquil Riad Elegancia where she stayed. She highlights the welcoming nature of the locals, the complexity of navigating the souks, and the indulgence of a traditional hammam spa treatment. The article also touches on the contrast between the historic medina and the modernity of the new town, with its global brands and the Jardin Majorelle. The piece concludes with a visit to the Agafay desert, emphasizing the diverse experiences Marrakech offers to travelers.

Eczema Care Online, an online behavioral intervention for atopic dermatitis (AD), has shown a small but sustained improvement in eczema severity over a year, according to studies presented at the International Society of Atopic Dermatitis meeting. The intervention, designed for parents of children with AD and young adults with AD, is low cost, evidence-based, and free from commercial bias, as stated by Dr. Kim Thomas of the University of Nottingham. The intervention was tested against usual care in trials involving 340 parents and 337 young patients, showing improved Patient-Oriented Eczema Measure (POEM) scores at 24 and 52 weeks. The intervention aims to provide consistent messaging across various healthcare contacts and is tailored to the UK health system. Dr. Natalie Cunningham from the Izaak Walton Killam Hospital for Children in Halifax commented on the importance of in-person education for eczema treatment, despite the potential benefits of online tools.

The updated Cochrane Review on infant skincare interventions to prevent atopic dermatitis (AD) and food allergy has found no benefit and a possible risk of harm from early emollient use. The review, led by Dr. Robert Boyle and co-authored by Dr. Maeve Kelleher and Dr. Hywel Williams, highlights concerns about the quality of systematic reviews in dermatology. Dr. Williams criticizes the proliferation of low-quality reviews and calls for adherence to PRISMA guidelines. The Cochrane Review, which used individual participant data (IPD) meta-analysis, is contrasted with other reviews that the authors consider less rigorous, including one by Dr. Xiaojing Kang and colleagues, which reached different conclusions about the effectiveness of emollients. The article emphasizes the importance of registered protocols for systematic reviews to ensure transparency and quality.

A study involving the Karolinska Institutet, University of Bristol, and Sun Yat-Sen University has found that childhood obesity is a risk factor for most subtypes of adult-onset diabetes, except for mild age-related diabetes. The study, which used Mendelian randomization and data from genome-wide association studies, found that larger childhood body size is associated with increased risks of developing diabetes subtypes in adulthood. The research identified genetic variations linked to obesity and diabetes, suggesting that some genes may affect both childhood body size and diabetes. The findings underscore the importance of controlling weight in children to prevent various forms of diabetes later in life. The study was supported by various councils and foundations, and one of the coauthors is employed by GlaxoSmithKline.

The TREAT study presented at the International Society of Atopic Dermatitis annual meeting compared the effectiveness of ciclosporin and methotrexate in treating severe atopic dermatitis (AD) in children. Led by Dr. Carsten Flohr of St John’s Institute of Dermatology and King’s College London, the study found that while ciclosporin provided a more rapid response, methotrexate offered more sustained disease control. The trial involved 103 pediatric patients who were assessed for changes in disease severity and quality of life. Despite a faster initial improvement with ciclosporin, methotrexate led to better long-term outcomes and fewer flares after treatment cessation. Safety profiles for both treatments were considered reassuring, with no significant differences in discontinuation rates. The study's implications are significant for treatment protocols and insurance coverage, as many regulatory bodies require the use of such conventional therapies before approving novel treatments. The research was funded by the National Institute for Health and Care Research.

A controversial study led by John Conly, MD, from the University of Calgary, suggests that surgical masks are not significantly less effective than N95 masks in protecting healthcare workers from COVID-19. The study, funded by the World Health Organization and others, has been criticized for being underpowered and methodologically flawed. Critics like Eric Topol, MD, and Raina MacIntyre, PhD, argue that the study's design and conclusions are inconsistent with existing evidence on the superiority of N95 masks. The study's findings have implications for health policy and worker safety, with some experts like David Fisman, MD, warning that it could justify inadequate protection measures. The study's authors and funders have various disclosures, including financial ties to organizations like Pfizer and 3M, which manufactures N95 respirators.

A study led by Dr. Neal Barnard found that a reduced-fat vegan diet with a daily serving of soybeans significantly reduced the frequency of menopausal hot flashes. The study, known as WAVS, involved 84 postmenopausal women and showed a 78% reduction in hot flashes for the intervention group over 12 weeks. The diet encouraged the avoidance of animal products, reduced fat intake, and included soybeans. Despite the positive results, Susan Reed, MD, president of the North American Menopause Society, advised caution due to the study's small size and nonblinded design. The study also explored the role of equol production but found no apparent effect on hot flashes. Dr. Barnard, who is affiliated with the Physicians Committee for Responsible Medicine and George Washington University, has written extensively on nutrition and health.

A systematic review and meta-analysis suggest that Solriamfetol (Sunosi), a norepinephrine-dopamine reuptake inhibitor, is more effective than other medications like modafinil-armodafinil and pitolisant for patients with obstructive sleep apnea (OSA) who experience residual daytime sleepiness despite conventional treatment. The study, which included over 3,000 patients across 14 trials, found that solriamfetol significantly improved scores on the Epworth Sleepiness Scale (ESS) and the Maintenance of Wakefulness Test (MWT). While solriamfetol may increase the risk of discontinuation due to side effects, it did not show evidence of serious adverse events in the short-term follow-up. The study, led by Dr. Tyler Pitre from McMaster University, also highlights the potential barriers to solriamfetol's use, such as comorbid hypertension and cost, and suggests that non-sleep specialists may not be fully aware of pharmacologic options for treating EDS in OSA patients.

A genetic variant, c.1108G>T, has been discovered in the Greenlandic Inuit population that significantly increases the risk of type 2 diabetes (T2D). This variant, found in 1.9% of the Inuit population, is linked to almost 7% of all diabetes cases in Greenland. Unlike other variants in the HNF1A gene that cause maturity-onset diabetes of the young (MODY), this particular variant leads to decreased beta-cell function without affecting insulin sensitivity. The study, led by Torben Hansen of the University of Copenhagen, also references another variant, TBC1D4, which together with c.1108G>T, accounts for a substantial proportion of T2D in Greenlanders. The research suggests potential for precision medicine, although specific treatments for carriers of the c.1108G>T variant are yet to be determined. The study was funded by various foundations and the findings were published in The Lancet Regional Health–Europe.

A retrospective study in Ontario, Canada, involving around 21,000 hospital visits for opioid use disorder (OUD) found that only 4.1% of patients received community-based opioid agonist therapy (OAT) within 7 days of discharge. The study, led by Dr. Tina Hu, highlighted the low rates of OAT initiation despite its effectiveness in reducing morbidity and mortality. The data, drawn from various sources including ICES, covered visits between January 2013 and March 2020. The study revealed missed opportunities to engage patients in treatment during critical periods and identified the majority of OAT prescribers as experienced male general practitioners. Dr. Hu cited lack of resources, training, and an overburdened healthcare system as reasons for underprescribing OAT. Michael-John Milloy, PhD, emphasized the need for improvement in acute care settings and the importance of community-based interventions. The study was funded by the Canadian Institutes of Health Research and supported by ICES.

A recent study suggests that adults with a history of clinically apparent Helicobacter pylori infection have an 11% increased risk for Alzheimer's disease compared to those without such exposure. The research, led by Paul Brassard, MD from McGill University, analyzed data from the UK Clinical Practice Research Datalink and found a moderate but statistically significant association between the infection and Alzheimer's disease. The study indicates that Helicobacter pylori infection could be a modifiable risk factor for Alzheimer's, but emphasizes the need for large-scale, randomized trials to confirm the impact of controlling this bacterium. The findings were published in the journal Alzheimer's & Dementia on December 13. Critics, such as David S. Knopman, MD from the Mayo Clinic, warn that the small effect size and potential for misdiagnosis of Alzheimer's in the study could lead to misleading conclusions.

A study published in JAMA Network Open has revealed a significant increase in hospitalizations for eating disorders among children in Ontario, Canada, from 2002 to 2019. The study, which included 11,654 pediatric cases, found a 416% increase in hospitalizations among boys and a 196% increase among 12- to 14-year-olds. The largest increase was seen in disorders other than anorexia or bulimia nervosa. Lead author Sarah Smith, MD, from the University of Toronto, expressed concern that stereotypes about eating disorders could lead to misdiagnosis and delays in treatment, especially in boys and younger patients. The study also noted an increase in co-occurring psychiatric diagnoses, indicating greater psychiatric complexity in patients. Jennifer Couturier, MD, from McMaster University, corroborated the findings with clinical observations and emphasized the need for clinicians to recognize atypical presentations of eating disorders.

A study led by John Conly, MD, suggesting that surgical masks are not significantly less effective than N95 masks in protecting healthcare workers from COVID-19 has been met with international criticism. The study, funded by the WHO and others, has been challenged for its design flaws by the CIDRAP and others. Critics like Eric Topol, MD, and Raina MacIntyre, PhD, argue that the study is underpowered and poorly designed, reinforcing existing biases. Kimberly Prather, PhD, and Trish Greenhalgh, MD, also question the study's rationale and implications for healthcare worker safety. Despite the criticism, lead author Mark Loeb, MD, defends the study's findings. The study's funding sources and the authors' potential conflicts of interest have been disclosed, with some having financial ties to mask manufacturers and other health organizations.

A study in British Columbia found that over 40% of individuals aged 80 and older remained uninfected by SARS-CoV-2 as of July 2023. The study, which included 4000 serum samples, revealed that younger individuals had higher infection rates, while those over 80 had the lowest. Dr. Danuta Skowronski, the lead author, emphasized the importance of prioritizing vaccines for seniors as they face the highest risk of severe outcomes. The study also highlighted that the risks for hospitalization and death from a first SARS-CoV-2 infection were low overall but increased with age. The research, published in the Canadian Medical Association Journal, was partly funded by the Public Health Agency of Canada and the Michael Smith Foundation for Health Research. It suggests that vaccination and previous infection history lower the risk of severe COVID-19 outcomes.

The Canadian Paediatric Society has released a position statement on diagnosing anxiety disorders in children and youth, providing guidance for healthcare providers. Dr. Benjamin Klein, the lead author and assistant clinical professor of pediatrics at McMaster University, emphasized the need for Canadian-specific guidelines amidst rising mental health issues and the impact of COVID-19. The statement includes recommendations for anxiety assessment, such as using the SCARED questionnaire and conducting thorough interviews. While the CPS document is endorsed by the Canadian Academy of Child and Adolescent Psychiatry, Dr. Joanna Henderson from the University of Toronto raised concerns about the lack of transparency in the methodology used to develop the guidelines. She suggests adherence to established quality criteria like the AGREE II checklist. Henderson also highlighted the importance of cultural competence in assessments and treatments. The article was written by Kate Johnson, a Montreal-based medical journalist.

A study published in the Canadian Journal of Neurological Sciences on October 16, 2023, reveals that patients with chronic migraine (CM) and medication overuse headache (MOH) tend to overuse acute pain medications and underuse preventive medications compared to those with episodic migraine (EM). The retrospective observational study included nearly 200,000 patients and found that opioids were the most frequently dispensed acute medication across all cohorts. The study, led by Dr. Farnaz Amoozegar from the University of Calgary, suggests that overprescription of opioids and underutilization of appropriate treatments may be due to a lack of education among primary care physicians, insufficient time for patient management, and long wait times for specialist consultations. The study also highlights the high healthcare costs associated with MOH and CM. Dr. Christine Lay of the Canadian Headache Society emphasized the importance of the study and the need for healthcare providers to adhere to guidelines, prescribe preventive therapy, and avoid opioids.

A study has found that Canadian wildfires, which caused smoke to drift into New York City from June 6 to June 8, 2023, led to a significant increase in emergency department visits for asthma syndrome. The study, authored by Kai Chen, PhD from Yale School of Public Health, reported that daily asthma-related ED visits rose to 261 from an average of 181.5 during reference periods. The study utilized New York's syndromic surveillance system and data from local US EPA monitoring stations, revealing that PM 2.5 levels spiked during the smoke wave. The increase in ED visits was observed across all age groups and boroughs, with Staten Island being the most affected. The study, which did not analyze the composition of the wildfire smoke, was published in JAMA. Other experts, such as George D. Thurston, ScD, and John Balmes, MD, commented on the findings, emphasizing the health impacts of wildfire smoke and the broader implications for air quality and climate change.

Tralokinumab, marketed as Adbry, has been found to be a safe and effective treatment for moderate to severe atopic dermatitis in adults aged 65 and older, according to a secondary analysis of the ECZTRA 1, 2, and 3 phase 3 trials published in JAMA Dermatology. The study, which included 104 older patients, showed that tralokinumab was more effective than placebo in achieving significant skin improvement and had a low incidence of severe adverse events. The drug, an interleukin-13 antagonist, was approved by the FDA in December 2021. The findings suggest that tralokinumab could be a safer option for older patients, who often have more severe disease and a higher risk of adverse events and drug interactions. The study was funded by LEO Pharma, and some authors disclosed financial ties to the company and other pharmaceutical firms. Dermatologist Ryoji Tanei from Tokyo also commented on the drug's safety and usefulness for the older population.

A pilot study involving 56 infants has explored the relationship between gut microbiota and early cognitive development. The study, conducted by researchers from the University of British Columbia and McMaster University, found that infants who passed the Point and Gaze test had higher levels of certain bacteria like Bifidobacterium and lower levels of others such as Streptococcus. The study used shotgun metagenomic sequencing to analyze the microbiome and employed neuroimaging techniques like fNIRS and EEG to assess brain activity. While the findings were not statistically significant and the study had limitations such as a small sample size, it suggests a potential link between microbiota and neurodevelopment. The research, funded by several Canadian institutes, was published in PLOS ONE on August 9, 2023. Experts not involved in the study highlighted the novelty of the research methods but also pointed out the need for larger, more robust studies to confirm these findings and their clinical relevance.

The article discusses the potential benefits of prescribing psychostimulants, such as methylphenidate and dextroamphetamine, to patients with stimulant use disorder in Canada. It highlights the crisis of drug poisonings, particularly from unregulated stimulants and synthetic opioids like fentanyl. The commentary, authored by Heather Palis and published in CMAJ, suggests that prescribed psychostimulants could reduce cravings and the use of illegal drugs. Despite evidence from clinical trials supporting this treatment, no pharmacologic treatments for stimulant use disorder are approved in Canada. British Columbia is the only province with a Safer Supply Policy Directive for prescribing psychostimulants. Elaine Hyshka, a health systems innovation expert, agrees with expanding access to prescribed psychostimulants and calls for national collaboration and stable funding for programs. The article also mentions the need for alternate routes of medication administration and nonmedical models of safer supply to address the broader population at risk of drug poisoning.

A new systematic review and meta-analysis published in JAMA Network Open has found that Janus kinase (JAK) inhibitors are significantly more effective than placebo in stimulating hair growth for patients with alopecia areata. The study, which analyzed seven trials with nearly 2000 patients, showed that oral JAK inhibitors are more effective than topical ones. The odds of achieving a 50% improvement in hair growth were over five times greater for those on JAK inhibitors. While the safety and tolerability were deemed acceptable, the study's authors, including Ming Liu, PhD, from McMaster University, call for longer trials to further assess these treatments. Dermatologist Jeff Donovan from the Donovan Hair Clinic commented on the importance of the findings and the need for continued research, despite recent FDA approvals of JAK inhibitors for alopecia areata. The study was conducted without external funding and no conflicts of interest were reported by the authors.

A study in Ontario, Canada, has found a decrease in benzodiazepine-related toxicity rates overall, but an increase among young adults aged 19-24. The study, which included nearly 26,000 patients, showed a decline in toxicity rates from 27.8 to 26.4 per 100,000 population between 2013 and 2020. However, the rate for young adults increased significantly, suggesting a rise in nonpharmaceutical benzodiazepine use. The study also noted a high rate of polysubstance involvement, with opioid toxicity being the most common. Researchers call for multifaceted public health approaches to reduce harm, including safe prescription practices, harm reduction services, and better integration of mental health care. The study was supported by various health organizations in Ontario and was published in the Canadian Journal of Public Health.

A study led by Dr. Sean M. Bagshaw from the University of Alberta found that nonvaccination against COVID-19 significantly increased the risk of hospitalization compared to vaccinated and boosted individuals in Alberta, Edmonton. The retrospective cohort study, published in the Canadian Journal of Public Health, covered the period from late September 2021 to late January 2022, during the fourth and fifth COVID-19 waves. It revealed that unvaccinated persons accounted for thousands of potentially avoidable hospitalizations and millions in healthcare costs. The study also highlighted the impact of low vaccine uptake in Alberta and the subsequent strain on the healthcare system, including the deferral of routine health services and the adoption of crisis standards of care.

Solriamfetol, a norepinephrine-dopamine reuptake inhibitor, is likely more effective than other wakefulness-promoting drugs for patients with obstructive sleep apnea who experience residual daytime sleepiness after standard treatment. A systematic review of 14 trials with over 3,000 patients showed solriamfetol improved the Epworth Sleepiness Scale score by 3.85 points compared to placebo. Dr. Tyler Pitre of McMaster University in Canada, the study's author, noted solriamfetol's superiority to the older and cheaper options modafinil-armodafinil. The study, published electronically on May 9 in Annals of Internal Medicine, also found high-certainty evidence that solriamfetol and modafinil-armodafinil improved the maintenance of wakefulness test compared to placebo. Side effects included headaches, insomnia, and anxiety, with headaches more likely with modafinil-armodafinil. While solriamfetol may increase blood pressure at higher doses, it does not reduce the efficacy of hormonal contraceptives like modafinil can. The study had no external funding, and both Dr. Pitre and Dr. Sogol Javaheri, who commented on the findings, declared no relevant financial conflicts of interest.

The article is a culinary guide by Kate Johnson on how to make polenta, a versatile dish that can be made from cornmeal or other grains and served soft or firm. The author discusses the different grinds of cornmeal and their cooking times, as well as the use of various liquids like broth, milk, and buttermilk to enhance the flavor. The article includes a personal anecdote about using buttermilk for polenta, resulting in a flavorful dish without the need for cheese. Two recipes are provided: one for basic polenta and another for semolina polenta, with instructions for both soft and firm versions. The author also shares tips for achieving a smooth texture and different cooking methods, including stove, instant pot, and oven.

Greenfield World Trade, Inc. has filed a lawsuit against Discount Bandit, LLC for trademark and copyright violations related to its food service and kitchen brands, including Omega, Vinotemp, Vinturi, and West Bend. The plaintiff alleges that the defendant's unauthorized use of their marks and product images will cause market confusion, harm their reputation, and reduce profits. The legal action includes claims of trademark counterfeiting, copyright infringement, and unfair competition, and seeks exemplary and punitive damages. The case is assigned to Judge Michael Brown in the Northern District of Georgia.

A study published in JAMA Network Open, led by Cary Wu from York University, has found that inflation stress disproportionately affects women and racial minorities in the United States. The research utilized data from the US Census Bureau's Household Pulse Survey, which included responses from September 2022 to February 2023. The findings revealed that women, Black and Hispanic respondents experienced higher inflation-related stress compared to men and White respondents. However, higher education and income levels were associated with lower inflation stress. The study suggests that socioeconomic status plays a role in the experience of inflation stress and highlights the need for research and policy development to address public health and prevent worsening health disparities. Wan‐Chin Kuo from the University of Wisconsin–Madison School of Nursing commented on the study, noting the importance of considering financial stress in context and the need for further research to understand the impact of inflation-related stress on health outcomes.

A study in Alberta, Canada, found that unvaccinated individuals had a significantly higher risk for COVID-19 hospitalization compared to those vaccinated or boosted, with nearly 10-fold and 21-fold increased risks, respectively. The study, led by Sean M. Bagshaw of the University of Alberta, indicated that nonvaccination resulted in thousands of avoidable hospitalizations and healthcare costs amounting to over $100 million Canadian dollars during the Delta and Omicron waves. The findings highlight the impact of low vaccine uptake on health system strain and the potential for preventable health service disruptions. Epidemiologist David Fisman commented on the study's consistency with other research and suggested that the economic benefits of vaccination are likely underestimated.

A systematic review and meta-analysis suggest that solriamfetol (Sunosi) is more effective than other medications like modafinil–armodafinil and pitolisant in treating residual daytime sleepiness in patients with obstructive sleep apnea (OSA) who are already on conventional treatment. The study, led by Tyler Pitre, MD from McMaster University, analyzed data from 14 trials with over 3000 patients, showing significant improvements in the Epworth Sleepiness Scale (ESS) and Maintenance of Wakefulness Test (MWT) scores. While solriamfetol showed a higher discontinuation rate due to side effects compared to other drugs, it did not present evidence of serious adverse events in the short term. The study also highlighted the need for awareness among non-sleep specialists about pharmacologic options for treating excessive daytime sleepiness (EDS) in OSA patients. The research was published in the Annals of Internal Medicine and did not receive outside funding.

The article by Kate Eagen Johnson discusses the exhibition 'Whistler: Streetscapes, Urban Change' at the National Museum of Asian Art's Freer Gallery of Art, part of the Smithsonian Institution. Curated by Dr. David Park Curry and Dr. Diana Jocelyn Greenwold, the exhibition focuses on James McNeill Whistler's depictions of European city scenes and their relevance to contemporary urban issues like gentrification. The Freer Gallery's collection is exclusively showcased, with some pieces being displayed for the first time since their acquisition. The exhibition also incorporates perspectives from local activists and urban planners through the Smithsonian's Hi mobile video guide. The article touches on Whistler's life, his artistic influences, and the transformation of London and Paris during his time. It also explores the connection between Whistler's work and Victorian-era merchandising, as well as the broader social implications of his art. The exhibition runs until May 4 and marks the 100th anniversary of the Freer Gallery of Art.

ABG EPE IP, LLC, the entity owning the intellectual property of Elvis Presley's estate, was granted a preliminary injunction against various non-U.S. entities accused of selling counterfeit goods that infringe upon the estate's trademarks. The defendants, who operate through online marketplaces such as Alibaba, Amazon, Walmart, and Wish, did not appear in court to oppose the motion. The court applied the standard four-factor test and found that all factors favored the plaintiff, Elvis's estate. The court's order includes a directive for financial institutions to freeze funds and for online marketplaces to disable listings of the infringing products. The injunction aims to protect the estate's trademarks and prevent consumer confusion over product authenticity and quality.

Canadian researchers have reported in JAMA Pediatrics that depression and anxiety among children and adolescents have increased during the COVID-19 pandemic, especially among females from higher income families. The systematic review and meta-analysis, led by Sheri Madigan, PhD, included 53 longitudinal cohort studies from 12 countries, analyzing data from over 74,000 participants. The study found a slight increase in anxiety symptoms and a stronger increase in depression symptoms, attributing these changes to pandemic-related disruptions and stress. The research also indicated that youth from higher-income backgrounds experienced larger increases in mental health issues, potentially due to greater digital device ownership and disruptions to routines. Jonathan Klein, MD, MPH, commented on the study, noting potential biases due to geographical location and the timing of data collection. Tracy Vaillancourt, PhD, and Daphne Korczak, MD, were also co-authors of the study, which calls for urgent government action to address youth mental health.

The article discusses the critical role of temperature at various stages of cheesemaking, from pasteurization to aging. It explains how different temperatures affect the safety, consistency, and flavor of cheese. The pasteurization process is detailed, noting that Vat Pasteurization and HTST are suitable for cheesemaking, while UP and UHT are not. The article also covers the importance of temperature during culturing, coagulation, cooking, pressing, and aging of cheese. It emphasizes that while the ingredients for making cheese are few, the variations in temperature throughout the cheesemaking process are what contribute to the vast diversity of cheese types. The article was originally published in the May/June 2023 issue of Goat Journal and is regularly checked for accuracy.

The article is a personal piece by Kate Johnson, a resident of Carson City, sharing her favorite seasoning and spice rub recipes suitable for grilling, smoking, or air frying. She provides detailed recipes for Slap Ya Mama Cajun Seasoning, Pork Dry Rub, Homemade Taco Seasoning, Fajita Seasoning, and a Chicken Dry Rub. Johnson mentions her preference for natural ingredients and provides tips on how to use these seasonings for various dishes, including omelets, ribs, tacos, fajitas, and chicken wings. She also expresses her fondness for her air fryer, which she uses frequently for cooking.

A study published in the Canadian Medical Association Journal has found that children who undergo four or more CT scans before the age of 18 have a significantly increased risk of developing certain cancers, including intracranial tumors, leukemia, and non-Hodgkin lymphoma. The research, led by Yu-Hsuan Joni Shao, PhD, from Taipei Medical University, utilized the National Health Insurance Research Database in Taiwan to analyze data from over 85,000 participants. The study emphasizes the importance of judicious use of CT scans and radiation protection strategies. Rebecca Smith-Bindman, MD, from the University of California San Francisco, commented on the study, suggesting that the true risks might be underestimated due to the study's conservative assumptions.

M+A Matting, LLC has filed a lawsuit against Entrymatsonline.com and 200 unnamed defendants for alleged trademark infringement and unfair competition. The Northern District of Georgia court, under Judge Batten, granted an ex parte temporary restraining order (TRO) to M+A Matting, requiring hosting sites and service providers to suspend the infringing domain and reveal the identities of the defendants. M+A Matting claims that Entrymatsonline.com willfully infringed on their trademark by using a similar mark and imitating their website, which could confuse customers and damage their brand. Despite attempts to serve cease-and-desist letters, the defendants remained unresponsive and elusive, prompting the court's ex parte action. The court found that M+A Matting demonstrated a likelihood of success on the merits, likelihood of irreparable harm, balance of harms in their favor, and that the public interest supports preventing trademark confusion. A hearing for a preliminary injunction is scheduled for May 8.

The Metropolitan Atlanta Rapid Transit Authority (MARTA) has filed a lawsuit in the Northern District of Georgia against an individual for the fraudulent and deceptive use of its registered trademarks. The suit, filed under the Lanham Act, aims to protect MARTA's incontestable marks, including its stylized word marks and distinctive logo, which have been in use since 1973 and registered since 2016. The defendant operates a business called MARTA Guide, which allegedly uses MARTA's name, website likeness, and social media presence to mislead consumers into believing there is an affiliation with MARTA for personal profit. Despite a cease and desist letter, the defendant has not responded, prompting MARTA to take legal action. The case is now before Judge Steve Jones.

In the legal case between Epic Tech, LLC and SpinX Games Limited, Northern District Judge Steve Jones partially granted SpinX's Motion to Dismiss, specifically dismissing the trademark dilution claim against SpinX. Epic Tech, a gaming hardware and software company, has been using the mark 'Ca$h Bash' since 2012 and accused SpinX Games, a social casino gaming company, of using a similar mark. While the court found that Epic Tech has standing to bring a false association claim, it dismissed the trademark dilution claim due to the mark not being sufficiently famous, comparing it to marks like Budweiser or Barbie, which are recognized by the general public. The court allowed Epic Tech to file an Amended Complaint within 21 days regarding the dilution claim.

American Dakota, Inc. (ADI), a Georgia-based textile design studio, has filed a copyright infringement lawsuit against Well Woven, Inc. (WWI) in the Northern District of Georgia. ADI, founded in 2009 by Mark Ford, alleges that WWI has been selling knockoff versions of its registered textile design, 'Old Crow-RED,' through various online platforms. The complaint claims that WWI's reproductions are made of low-quality polypropylene, in contrast to the original's nylon material. The lawsuit includes counts for Copyright Infringement, Deception or Unfair Trade, and Addition of False Copyright Management Information. The case is presided over by Judge Steven Grimberg.

The article discusses the collaboration between New York oncologist Dr. Gabriel Sara and French actress and director Emmanuelle Bercot, which led to the creation of the film 'Peaceful' (De Son Vivant). Dr. Sara, who has no formal acting training, was cast to play himself in the film, which premiered at the 2021 Cannes Film Festival and was nominated for Best Film at the 2022 Lumières Awards. The film, based on Dr. Sara's philosophy of honesty in cancer treatment, tells the story of a man with stage 4 pancreatic cancer and his journey to acceptance of his condition. Dr. Sara's approach to patient care, which includes tango performances and music sessions, is highlighted as a means to help patients and staff cope with the emotional challenges of cancer treatment. The article also touches on Dr. Sara's recent retirement and his methods for avoiding burnout during his 40-year career.

The phase 3 ADvocate1 and ADvocate2 trials, published in the New England Journal of Medicine, demonstrated that lebrikizumab, an interleukin-13 inhibitor, is effective and safe as a monotherapy for atopic dermatitis (AD) during a 16-week induction period. The trials, which were randomized, double-blind, and placebo-controlled, involved 851 adolescents and adults with moderate to severe AD. The primary efficacy outcomes were met by a higher percentage of patients treated with lebrikizumab compared to placebo. The study also noted a significant improvement in skin clearance, itch, and sleep quality for patients on lebrikizumab. Conjunctivitis was the most common adverse event among lebrikizumab patients. The research was supported by Dermira, a subsidiary of Eli Lilly, and several authors disclosed financial relationships with these companies. Independent expert Zelma Chiesa Fuxench commented on the promising results and the potential for reduced injection frequency after initial disease control.

In Canada, the quality of palliative care is substandard, with patients facing issues such as inadequate pain management and end-of-life care. Dr. Justin Sanders of the Montreal University Health Centre highlighted these concerns following a high-profile complaint about the care at St. Mary's Hospital in Montreal. Dr. Ebru Kaya, president of the Canadian Society of Palliative Care Physicians, concurred, noting Canada's poor global ranking in palliative care. The lack of mandatory training for non-palliative care physicians and absence of regulatory frameworks are contributing factors to the problem. Both Sanders and Kaya advocate for urgent reforms and better education for physicians to improve palliative care services. Sanders, who previously worked at Ariadne Labs in Boston, emphasizes the importance of early palliative care initiation and symptom management. Individual efforts by clinicians to improve their palliative care skills, such as taking courses offered by Pallium, can make a difference within the current system.

The article discusses the results of phase 3 ADvocate1 and ADvocate2 trials for the drug lebrikizumab, an interleukin-13 inhibitor, used as a monotherapy for atopic dermatitis (AD). The trials, which were randomized, double-blind, and placebo-controlled, showed that lebrikizumab was effective and safe during the 16-week induction period. The study, led by Dr. Jonathan Silverberg of George Washington University, indicated rapid improvement in skin clearance and itch relief. Although long-term safety could not be assessed in this period, the safety profile was consistent with previous findings. The research was supported by Dermira, a subsidiary of Eli Lilly, and several authors disclosed financial relationships with these companies. Dr. Zelma Chiesa Fuxench, not involved in the research, commented positively on the results, highlighting the potential for reduced injection frequency after initial disease control.

A trademark dispute between Jekyll Island-State Park Authority and Polygroup Macau Limited was dismissed by the Southern District Court of Georgia due to lack of personal jurisdiction. The court found that Polygroup did not have sufficient minimum contacts with Georgia for specific or general jurisdiction. The ruling also dismissed JISPA's state common law trademark and unfair competition claims, as well as a trademark cancellation counterclaim. JISPA's federal claims were dismissed because they did not arise from Polygroup's contacts with the state, and the Court could not establish general jurisdiction over Polygroup based on US-based trademark activities.

The article is a personal narrative by Kate Johnson, who expresses her fondness for chopped salads and shares her ideas for creating various types of these salads. She provides a detailed recipe for a Mexican Chopped Salad, which serves four and includes ingredients like purple cabbage, purple onion, roasted corn, avocado, jalapeño pepper, cilantro leaves, and Cotija cheese. Additionally, she offers two dressing options: a creamy Mexican dressing with mayonnaise or Greek yogurt and a Mexican vinaigrette with avocado oil and Hatch Chili Infused Olive oil. Beyond the Mexican Chopped Salad, Johnson suggests other ingredients for creating different chopped salads, including a variety of vegetables, cheeses, proteins, and dressing flavorings. She also shares a personal favorite chopped salad recipe that includes smoked trout and a dressing made with mayo, wasabi, and soy sauce, likening the taste to an expensive sushi bowl.

Polaris Experience, LLC has filed a complaint in the Northern District of Georgia against a former authorized outfitter of Polaris Slingshot motorcycles. The lawsuit alleges that the Defendant violated their agreement by retaining 67 Slingshot vehicles after termination, resulting in multiple thefts. Furthermore, the Plaintiff accuses the Defendant of misusing Polaris trademarks on a rental website and social media, falsely presenting themselves as authorized outfitters, and causing consumer confusion. The case is presided over by Judge Eleanor Louise Ross.

The article is a travelogue by Kate Johnson, who describes her experiences at the Aurora Safari Camp in Swedish Lapland, located about 25 miles south of the Arctic Circle. She recounts the mesmerizing sight of the aurora borealis and the camp's amenities, including new wooden-framed rooms with floor-to-ceiling windows for night sky viewing. The camp offers a balance of solitude and sociability, with facilities for comfort despite its remote location. Kate also shares her adventure of a hot-air balloon ride with pilot Björn, emphasizing the serene beauty of the landscape from above and the unique experience of spotting wildlife. The article concludes with her unexpected plunge into the icy waters of the Råne river, highlighting the invigorating and wondrous aspects of the region. Travel details and costs are provided for readers interested in similar experiences.

Judge Leigh Martin May has denied the Harlem Globetrotters' request for expedited discovery in their legal dispute with Sunset Pictures, LLC. The Globetrotters sought to enforce a preliminary injunction to prevent a film depicting the team from being screened on February 17, 2023. The court found the request for such an aggressive schedule unreasonable, especially given the court's current engagement in a criminal trial. The judge also noted that the limited initial showing of the film did not warrant the extraordinary relief sought by the Globetrotters. The court's existing schedule was deemed sufficient to address the issues before the film's nationwide release in April 2023.

The Harlem Globetrotters have filed a lawsuit against Sunset Pictures, LLC, and Briarcliff Entertainment LLC for unauthorized use of their trademarks in social media promotions for the upcoming film 'Sweetwater.' The film is about the life of 1950s basketball star Nathaniel 'Sweetwater' Clifton. The Globetrotters claim that the defendants have infringed and diluted their federally-registered trademarks and engaged in unfair competition under the Lanham Act. Despite attempts to resolve the issue out of court, the defendants have been uncooperative, leading to the need for judicial intervention. The case is now before Judge Leigh Martin May, and an emergency motion for expedited discovery has been filed by the plaintiff.

The article by Kate Eagen Johnson discusses the exhibition 'Life and Art: The Greenwich Paintings of John Henry Twachtman' at the Greenwich Historical Society in Cos Cob, Connecticut. It explores the influence of the local landscape on Twachtman's work during his Greenwich period in the 1890s. The exhibition, curated by Dr. Lisa N. Peters, features 18 works, photographs, and archival items, and is complemented by a thematic installation of the Bush-Holley House and various programming. The article also mentions the John Henry Twachtman Catalogue Raisonné, an online resource authored by Peters. Twachtman's artistic evolution, his role as a founding member of The Ten, and his teaching at the Art Students League are highlighted. The article concludes with details about the exhibition's run and contact information for the Greenwich Historical Society.

A patent lawsuit in the Northern District of Georgia between Johnson Controls Technology Company and Price Industries Inc. was settled shortly after a Claim Construction Order was entered by Judge Leigh Martin May on December 2, 2022. The case, involving allegations of patent infringement on HVAC systems equipment, was resolved after two years and 103 days, with the settlement reached 14 days after the order. The case was dismissed on December 16, 2022.

The EPI-CT study, led by Michael Hauptmann, PhD, from the Institute of Biostatistics and Registry Research at Brandenburg Medical School, has found that children and young adults exposed to CT scans before age 22 are at a higher risk of developing brain tumors, especially gliomas. The study, which included over 650,000 individuals from nine European countries, showed a significant association between the number of CT scans and the risk of brain cancer. The research emphasizes the need for judicious use of CT scans and minimizing radiation doses. Rebecca Bindman-Smith, MD, from UCSF, highlighted the importance of informed decision-making regarding CT scans and the potential risks involved. The study was published in The Lancet Oncology and suggests regulatory oversight to ensure the lowest possible radiation doses during CT scans.

A clinical trial has shown that a single dose of the experimental drug acoziborole has a cure rate of over 95% for human African trypanosomiasis (HAT), also known as sleeping sickness. The study, led by Antoine Tarral of the DNDi and published in The Lancet, involved 208 participants from the Democratic Republic of the Congo and Guinea. Acoziborole, co-developed by DNDi and Sanofi, offers a simpler treatment method compared to current WHO guidelines, which require hospitalization. The drug's effectiveness across all stages of the disease could facilitate a screen-and-treat approach at the village level, potentially aiding in meeting the WHO 2030 goal to end transmission of HAT. The study faced challenges due to the declining incidence of HAT and was designed as an open-label, single-arm trial without a control group. Serious adverse events were reported in 10% of patients but were not considered drug-related. A larger, double-blind, placebo-controlled trial is underway to increase the safety data.

A study has found that people living with HIV (PLWH) experience mistimed circadian phases and shorter sleep compared to HIV-negative individuals, suggesting a potential mechanism for increased comorbidities in PLWH. The study, involving participants from the HAALSI study in South Africa, indicates that circadian misalignment in PLWH could be a constant feature of chronic HIV infection, potentially affecting sleep and physical health. The findings propose that light therapy or chronobiotic medication could alleviate these issues.

A study published in The Lancet by Mohsen Naghavi and the GBD 2019 Antimicrobial Resistance Collaborators reveals that 33 bacterial pathogens were responsible for over one-seventh of global deaths in 2019, ranking second only to ischemic heart disease. Staphylococcus aureus was identified as the leading cause of bacterial death in 135 countries, and Streptococcus pneumoniae was the most deadly for children under 5. The study, which excluded Mycobacterium tuberculosis, used various data sources to estimate the impact of bacterial infections across 204 countries and 11 infectious syndromes. It highlighted the need for interventions such as infection prevention, vaccination, acute care services, and the development of new antibiotics. The study also discussed the challenges of addressing antimicrobial resistance (AMR), with a perspective published in PLoS Biology emphasizing the urgency of refocusing on AMR. Funding for the research came from the Bill & Melinda Gates Foundation, Wellcome Trust, and the UK Department of Health and Social Care's Fleming Fund.

The article discusses the challenging reality of achieving a six-figure income through self-employment, highlighting the high failure rates and market saturation that entrepreneurs face in the United States. It presents statistical data showing a grim outlook for those aiming to reach $100k in gross receipts, with only a 0.75% chance of success. The piece then shifts to discuss strategies for overcoming these challenges, such as acquiring the right knowledge and skills, focusing on wealthy markets, mastering marketing, differentiating oneself, engaging in massive transactions, and offering in-demand products or services. The article introduces Stryde, a company that claims to have created the 'Cost Remediation' market, offering unique strategies and systems to help businesses enhance revenue, mitigate taxes, and reduce expenses, positioning itself as a solution to the difficulties faced by self-employed individuals and businesses seeking to increase their income.

The article discusses the challenges faced by professionals in maximizing their income due to market saturation, technological advancements, and market concentration. It highlights how these factors have led to increased competition, a more informed consumer base, and a focus on declining target markets. The solution proposed is to shift focus to underserved markets with significant economic power, leverage technology that complements one's core competencies, and target Main St. Businesses. Stryde is presented as a company that specializes in helping small businesses increase cash flow, reduce taxes, and cut operating expenses through its comprehensive software, positioning itself as a valuable partner for professionals seeking to have their biggest year ever by tapping into a competition-free market space.

The article discusses the Employee Retention Tax Credit (ERC), a significant tax credit available to U.S. businesses as part of COVID-19 relief efforts. It explains the expansion of the ERC through the CARES Act and the American Rescue Plan Act, detailing the eligibility criteria and benefits for 2020 and 2021. Businesses can claim a substantial amount per employee, with the potential to receive a refund from the IRS if the credit exceeds their employment tax liability. The article also highlights the complexity of the program and the importance of seeking professional assistance, mentioning Kate Johnson as the local ERC Expediter for Oregon and the Growth Management Group as a resource for claiming the credit.

The article discusses the current trend of employees leaving their jobs en masse, a phenomenon that has left many small business owners struggling to find and retain staff. The author suggests that the pandemic has caused a shift in employee priorities, with many seeking meaningful work that aligns with their values rather than just a paycheck. Small businesses are positioned to capitalize on this trend by offering a vision and passion that resonates with local communities. The article also highlights new cash flow incentives available for small and mid-sized businesses to help them hire and pay new staff, suggesting the use of software to identify and apply for these programs.

The article discusses the results of the STREAM stage 2 study, which tested bedaquiline-containing treatment regimens for rifampicin-resistant tuberculosis (TB). The study found that a 9-month and a 6-month bedaquiline-based oral regimen were superior to the 9-month injectable control regimen, offering better efficacy and less ototoxicity. The findings support the WHO's recommendation for a bedaquiline-based oral regimen. The study was conducted across seven countries and involved 517 participants. Despite the positive outcomes, the study noted high levels of adverse events and emphasized the need for safer and more tolerable treatments. The study was funded by USAID and Janssen Research and Development. The article also includes comments from experts who highlight the need for improved drug-susceptibility testing to minimize resistance to bedaquiline.

Judge Thomas W. Thrash, Jr. of the Northern District of Georgia denied ExeGi Pharma, LLC's request for Letters Rogatory to conduct an oral deposition of a non-party witness in Italy. The request was deemed untimely, dilatory, and unnecessary. The Plaintiff sought to use Letters Rogatory under the Hague Evidence Convention but initiated the process too late into the nine-month window provided for international discovery. Judge Thrash suggested that the Plaintiff could obtain the necessary testimony through traditional discovery methods in the United States. The denial emphasizes the importance of timeliness in requests for foreign discovery. The case continues in the Northern District of Georgia.

The article is a personal story and recipe shared by Kate Johnson, a resident of Carson City. She recounts receiving an abundance of squash from her friend, including a large zucchini. Kate shares her recipe for 'Oops, I Forgot to Lock the Car Door Stuffed Zucchini,' which is a versatile dish that can incorporate various garden vegetables. The recipe includes ingredients such as zucchini, olive oil, onion, garlic, mushrooms, sausage, tomato paste, spices, fresh tomatoes, cream sherry, and cheese. The cooking instructions are straightforward, involving sautéing, boiling, and baking. The article provides a homely and practical solution for using excess garden produce.

The article discusses the importance of proper snow removal strategies to prevent flooding and water damage caused by rapid snowmelt. It highlights that an inch of snow can produce approximately 3000 gallons of water when melted and emphasizes the risks of flooding, which can lead to costly repairs. The article recommends purchasing flood insurance and outlines specific areas to focus on for snow removal, including the roof, around the home, and the yard. It advises using tools like roof rakes and shovels for fresh snow removal and suggests hiring professional water damage removal companies if necessary. The article also stresses the importance of maintaining clear gutters and passageways to ensure proper drainage and prevent water from pooling near the foundation, which could compromise the structural integrity of a property.

A study found that people living with HIV (PLWH) experience mistimed circadian phases and shorter sleep compared to HIV-negative individuals with similar lifestyles, suggesting a mechanism for increased comorbidities in PLWH and potential solutions like light therapy or chronobiotic medication. The study, part of the HAALSI study in South Africa, involved 187 participants and used actigraphy and dim light melatonin onset (DLMO) to measure sleep patterns. Results showed later melatonin production and sleep onset, and earlier waking in PLWH. The study, supported by the Academy of Medical Sciences, provides direct evidence for potential circadian disturbances in PLWH and suggests further research is needed.

The TREAT study presented at the ISAD annual meeting compared the effectiveness of ciclosporin and methotrexate in treating severe atopic dermatitis in children and young people. The study found that while ciclosporin provided a more rapid response, methotrexate offered more sustained disease control. The trial involved 103 patients and measured outcomes such as disease severity and quality of life. Despite more nonserious adverse events in the methotrexate group, the safety of both treatments was considered reassuring. The study's findings are significant for regulatory bodies regarding the use of first-line conventional systemic therapies before novel therapeutics. The study was funded by the National Institute for Health and Care Research and presented by lead investigator Carsten Flohr, MD, PhD.

The BEEP trial, presented at the ISAD annual meeting, showed that daily use of emollients in infants at high risk for atopic dermatitis (AD) did not prevent the condition more effectively than standard skin-care advice. The study, led by Hywel C. Williams from the University of Nottingham, followed 1394 infants for five years and found no significant difference in the development of AD or related disorders between the emollient group and the control group. Despite earlier positive results from the smaller STOP-AD trial, the BEEP trial's findings suggest that emollients may not prevent eczema. Panelist Eric Simpson and dermatologist Aaron Drucker highlighted the need for further research and noted that while emollients may not prevent AD, they also do not appear to cause harm.

A study presented at the International Society of Atopic Dermatitis (ISAD) 2022 conference in Montreal suggests that remote assessment of atopic dermatitis (AD) severity using patient-provided photos is feasible. The study, conducted by Dr. Aviël Ragamin from Erasmus MC, University Medical Center Rotterdam, included 87 children and compared in-clinic Eczema Area and Severity Index (EASI) scores with self-administered scores based on patient-provided images. While the study found good reliability in image assessments, there were challenges with image quality and patient participation. Only a small percentage of parents provided usable images. Dr. Aaron Drucker from Women's College Hospital and the University of Toronto commented on the practical difficulties of using remote photography in clinical practice but noted potential benefits for clinical trials. No financial conflicts were disclosed by the investigators.

A retrospective review published in the journal Allergy has reported that nearly two-thirds of adults undergoing oral immunotherapy (OIT) for various food allergies at the Shamir Medical Center in Israel achieved full desensitization. The study, which is the largest adult OIT cohort to date, included 93 adults and compared their outcomes with those of children and adolescents treated for milk, peanut, sesame, egg, or tree nut allergies. While the success rate for non-milk allergens was high, milk allergy proved more challenging, with lower success rates and more severe reactions. The study's lead author, Na'ama Epstein-Rigbi, MD, suggests that milk allergic patients should seek treatment at younger ages to increase success rates. Richard Wasserman, MD, PhD, an expert not involved in the study, commented on the findings, noting the importance of reducing the risk of reactions from accidental exposure and the difficulty of milk OIT. The study's methodology may differ from North American protocols, which could affect the applicability of the findings in other regions.