Sotagliflozin, a dual SGLT1 and SGLT2 inhibitor, has been shown to significantly reduce the risk of cardiovascular death and heart failure hospitalizations when administered before hospital discharge for worsening heart failure (WHF) in patients with type 2 diabetes. A post hoc analysis of the SOLOIST-WHF trial focused on the effects of sotagliflozin 30 and 90 days after discharge, revealing a more than 40% decrease in cardiovascular mortality and HF-related events, as well as a significant reduction in total mortality at 90 days post-discharge. The safety profile of sotagliflozin was consistent with selective SGLT2 inhibitors, and the findings suggest that early initiation of evidence-based heart failure therapy can improve patient outcomes and potentially reduce healthcare costs.

The study examines the impact of removing the race-specific coefficient from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation on the inclusion of Black participants in clinical trials and the assessment of kidney function. The analysis, using data from the CREDENCE trial, suggests that eliminating the coefficient could decrease the likelihood of Black participants being randomized in trials due to shifts in estimated kidney function. The study highlights the potential implications for trial design and interpretation, emphasizing the need for additional research to understand the effects of such changes.

Christopher Cannon, a third-year student studying English and history, shares his personal struggles with toxic family relationships, particularly with relatives on his father's White side who hold subtle anti-Black ideologies. He describes the conflict between maintaining a traditional family image and his own mental and emotional stability. Cannon has chosen to distance himself from these family members, refusing to sacrifice his self-respect and self-love. He emphasizes the importance of being conscientious and holding family members accountable for their beliefs, especially when they perpetuate institutionalized discrimination. Cannon encourages others to confront toxic family members and not to be complicit in the face of injustice.