The study investigates the expression of mismatch repair (MMR) proteins and PD-L1 in colorectal cancer (CRC) patients and their correlation with clinicopathological characteristics and therapeutic efficacy. A retrospective analysis of 272 CRC patients from Nanjing Drum Tower Hospital was conducted, focusing on the expression of MMR proteins MLH1, PMS2, MSH2, and MSH6, and PD-L1 protein, using immunohistochemistry staining. The study found that MMR protein expression deficiency was significantly correlated with tumor location, TNM stage, and degree of differentiation, while PD-L1 positivity was associated with TNM stage. Survival analysis indicated that patients with proficient MMR (pMMR) had better progression-free survival compared to those with deficient MMR (dMMR). The study suggests that MMR and PD-L1 expression in CRC tumor tissue is related to pathological features and patient prognosis, with pMMR patients generally having a better prognosis than dMMR patients.

A study analyzing national patient-level data on rectal cancer surgery within the English National Health Service from April 2015 to March 2019 found that hospitals in competitive environments and those that were successful competitors had better patient outcomes. Patients in competitive areas were less likely to undergo surgery with permanent stoma formation, and those treated at successful competitors had lower risks of 90-day readmission and persistent stoma 18 months post-surgery. The study challenges the centralization of cancer surgical services and suggests that hospital competition can drive improvements in care quality.

Selenium nanoparticles (SeNPs) have been synthesized in various forms such as nanowires, nanorods, and nanotubes, and are increasingly used in biomedical applications due to their high bioavailability and bioactivity. They are particularly useful in treating oxidative stress-induced cancers, diabetes, and other diseases. However, pure SeNPs face stability issues, which can be overcome through surface functionalization strategies that improve their biological activity. This review discusses the synthesis methods, surface functionalization strategies, and applications of SeNPs in treating brain diseases.

The study presents the development of a novel recombinant rabbit anti-myoglobin monoclonal antibody and its potential application in diagnosing and treating rhabdomyolysis-associated acute kidney injury (RM-AKI). The antibody demonstrated high affinity, broad species reactivity, and good tissue specificity. It was effective in detecting myoglobin deposition in kidney tissues in a mouse model of RM-AKI, suggesting its usefulness in medical diagnostics and possibly as a treatment for RM-related diseases.

A BiPO4/Ov-BiOBr type-I high-low junction photocatalyst was synthesized using a two-step solvothermal method, demonstrating superior photocatalytic activity for tetracycline degradation and hydrogen peroxide production under visible light. The optimal molar content of BiPO4 was found to be 10%, which showed the highest degradation rate and efficiency. The study revealed that the heterojunction structure, bandgap matching, and efficient charge separation contributed to the enhanced performance. The main active species in the photocatalytic process were identified as hydroxyl and superoxide radicals. The research provides a new approach for developing efficient visible-light photocatalysts and has potential environmental purification applications.

The study investigates the interfacial properties of betaine mixtures and their synergistic effects with anionic surfactant petroleum sulfonate (PS) and extended anionic surfactant alkoxyethylene carboxylate (AEC) in high-temperature and high-salinity reservoir conditions. It explores the impact of temperature-resistant, salt-resistant polymers with varying contents of 2-acrylamide-2-methylpropanesulfonic acid (AMPS) on dynamic interfacial tensions (IFTs) against n-alkanes and crude oil. The research finds that the IFTs between betaine ASB and n-alkanes can be significantly reduced by compounding with PS and AEC. The study also reveals that the addition of water-soluble polymers enhances the water solubility of both ASB@PS and ASB@AEC, affecting the IFTs by regulating the hydrophilic-lipophilic balance (HLB). The findings have implications for the design of enhanced oil recovery formulations in challenging reservoir environments.

The article discusses the self-assembly, collective behavior, and potential applications of perovskite nanocrystal superlattices. It is authored by D. Yan, Q. Shan, Y. Dong, L. Han, X. Wu, Y. Peng, and H. Zeng and published in Chemical Communications in 2023.

The study investigates the mechanical properties of 7B04-T74 aluminum alloy in a marine atmosphere, focusing on corrosion effects and their impact on tensile and fatigue properties. The research, conducted by authors from Beihang University, China, reveals that the alloy is sensitive to marine atmospheric conditions, primarily experiencing pitting corrosion without significant intergranular or exfoliation corrosion. Tensile properties remain largely unaffected by corrosion, while fatigue properties show a significant decrease, with fatigue life reduced by at least 93% upon the occurrence of pitting corrosion. The study concludes that pitting corrosion significantly affects the crack initiation stage, reducing the crack initiation life of the aluminum alloy.

China's spot copper trading is expected to remain slow in Q1 2022 due to high inventories and power restrictions affecting smelters in Guangxi and Yunnan. Smelters have increased term contracts to minimize exposure to spot treatment charge volatility, with many securing 90% of their production needs through these contracts. Spot treatment charges (TCs) for Q1 2022 were heard in the mid-$60s/mt, with term contracts mostly concluded at around $60/mt. Despite an increase in copper concentrate supply, demand for clean copper concentrates remains stable, with small to medium-size smelters preferring standard clean concentrates. The market is also adjusting to an unprecedented backwardation in concentrate pricing terms and preparing for production cuts due to the Beijing Winter Olympics and planned plant maintenance.